Miss Margaret Frances Mauro was born in Washington, DC on 14 September 1882. She was the daughter of Missouri-born attorney Philip Mauro and the former Emily Johnston Rockwood of Boston. She had a younger sister, Isabel. 

Part-educated in France, as a young girl Margaret showed a gift for rhyming and poetry and by the time she had reached 14-years of age she had already had some of her work published, which was described as remarkable for a mind of that age. After schooling she followed in her father’s evangelical footsteps and often hosted religious meetings around the east coast; in the mid-1900s she took charge of a Baptist mission for Italian migrants in Washington. 

In April 1912 Margaret Mauro and her father Philip were first cabin passengers aboard the Carpathia when that ship rescued the survivors of the Titanic disaster. They continued on to Europe after the survivors had been landed in New York, spending time in Italy.

Miss Mauro never married and continued her evangelical Christian and missionary work. In later years she acted as a governess to wealthy Washington families.

Margaret Frances Mauro died in Staunton, Virginia on 28 May 1948 following a stroke and was buried in the Masonic Cemetery in Culpeper, Virginia. She was survived by her father Philip and her sister Isabel.