Mr Frank Manley Warren was born in Ellsworth, Hancock, Maine on 10 May 1848.

He was the son of Francis Manley Warren (1817-1900), a merchant, and Elizabeth Dyer (b. 1817-1893), both Maine natives.

Frank first appears on the 1850 census as an infant living with his mother at the home of his maternal grandmother Sarah Dyer (b. 1775) in Castine, Hancock, Maine. By the time of the 1870 census Frank and his family were living in Portland, Oregon and he was described as an express office clerk. He later founded the Warren Packing Co, a fish canning company, and the community of Warrendale, Oregon, the site of one of his canneries, was named after him.

In 1872 Frank was married to Oregon native Anna Sofia Bates Atkinson (b. 1851), the daughter of a missionary, the Reverend George Henry Atkinson. The couple had four children: Frances Elizabeth (1873-1960, later Mrs Walter Alfred Holt), Frank Manley (1876-1947), George Atkinson (1878-1938) and Anna Grace (1881-1977, later Mrs Donald R. Munro). The Warrens were active in their local community and members of the First Congregational United Church of Christ in Portland. Frank also served on the board of trustees of Pacific University, which was co-founded by his father-in-law.

In early 1912 the Warrens had been spending a three month-long vacation in Europe in celebration of their 40th wedding anniversary when they were returning to the USA. They boarded the Titanic at Cherbourg travelling as first class passengers (ticket number 110813 which cost £75, 5s) and they occupied cabin D-37.

Mrs Warren later recalled events of 14 April:

"After dinner in the evening and until about 10 p.m. we were seated in the lounge on the dining saloon deck listening to the music. About the time stated we went to one of the upper decks, where Mr. Warren wanted to take a walk, as was his custom before retiring. He did not, however, as the temperature had fallen very considerably and the air was almost frosty, although the night was perfect, clear and starlight... We retired about 10.30, ship's time and we went to sleep immediately. About 11.45, ship's time, we were awakened by a grinding noise and the stoppage of the vessel. Our room was on the starboard side of deck D, about 30 (?) feet above the water and in line with the point of impact... I arose immediately, turned the lights on and asked Mr. Warren what terrible thing had happened. He said 'nothing at all,' but just at that moment I heard a man across the corridor say, 'we have certainly struck an iceberg.' I then asked Mr. Warren to go and see what was the matter. He first started out partly dressed, but decided to dress fully before going out; after doing which he went to one of the corridors and returned in a very few minutes with a piece of ice, saying it had been handed him as a souvenir. By that time I had dressed and had laid out the lifebelts but Mr. Warren said there was absolutely no danger and that with her watertight compartments the vessel could not possibly sink and that in all probability the only effect of the accident would be the delaying of our arrival in new York three or four days. We felt, however, too restless to remain in our room, so went out in the corridor again and talked with both the employees of the vessel and passengers. The general opinion prevailing was, that there was no danger except for the expression on the part of one man who stated that the water was coming in below forward.

Whilst waiting in the corridors the Warrens spotted one of the H&W guarantee group rushing past towards the stairs, electrician, William Henry Marsh Parr (misidentifying him as Mr Perry) and they asked him for an explanation of what was happening. He didn't reply and brushed past. The Warren's continued to wait around the staircase, for what Mrs Warren thought was around 45 minutes, when a steward came and asked them to put on their lifebelts and head topside. They returned to their cabin to fetch their lifejackets  and ascended to the boat deck where they encountered the Astors and Helene Østby, the latter who had become separated from her father. The group remained together but Mrs Warren said that the Astors later went inside and she never saw them again that night.

Beckoned towards one of the lifeboats (boat 5), Mrs Warren stepped into the craft and expected her husband to follow. When she looked around, despite the dark, she saw him assisting other ladies into the boat. She never saw him again.

Frank Warren lost his life in the disaster. His body, if recovered, was never identified.