My knowledge on these matters is relatively limited, since, on a day to day basis, I deal with statics rather than dynamics - I leave that more complicated stuff to you guys!
However - one small point that may (or may not!) be appropriate...
Whilst any reciprocating engine will always produce some vibration (which can hammer the bejesus out of mounting bed!) - a well designed, carefully run power unit can be set to run at an appropriate speed to limit this vibration to within quite acceptable parameters, as has been pointed out.
But when you are considering more than one engine, you can have the added effect of synchronisation and harmonic resonance to deal with. This can be a particularly delicate 'balancing act' on large multi-engined aircraft with reciprocating engines.
Indeed, one or two examples spring to mind (particularly one or two German WWII twin, and tri-motor bombers) where it was normal practise to ensure that the motors were running 'out of synch.' to avoid a harmonic resonance cycle being established.
Such a cycle (where, at periodic intervals, one cylinder on one engine 'fires' at exactly the same moment as a cylinder on a second power unit) can produce a substantial hammering to the structure of any aircraft or vessel - not to mention being damned irritating to everyone on board!
Just a thought....
John M